Anti-Mullerian hormone: AMH is a 140 kDa, disulfide-linked, homodimeric glycoprotein, a member of the transforming growth factor-beta family (TGF-beta) of the growth and differentiation factor superfamily, First discovered in 1947 by Professor Alfred Jost. In males AMH is secreted by immature Sertoli cells of the testis, in females AMH is secreted by granulosa cells of ovarian preantral follicles and small antral follicles, and AMH is involved in the degeneration of the Mullerian ducts. AMH is one of the best indicators to reflect ovarian reserve.
Clinical significance
Obstetrics and Gynecology: assessment of ovarian reserve; (fertility prediction, perimenopausal management)
Assess for Premature Ovarian Failure; Assess for Polyovarian Syndrome; Assess for Female Tumors; (Granular Cell Tumor of Ovarian)
Reproductive Center: Assess ovarian responsiveness;
Physical examination applications: assess ovarian function and status;
Pediatrics: gonadal development assessment, etc.;