Soluble vascular endothelial growth factor receptor 1 (sVEGFR-1), also known as soluble fms-like tyrosine kinase-1 (sFlt-1), was originally discovered in human umbilical vein endothelial cells and is a tyrosine kinase Active glycoprotein formed by different splicing methods from VEGFR-1 mRNA. sFlt-1 is a factor found in recent years that is believed to play an important role in anti-angiogenesis, mainly produced by the placenta, and plays a role in the blood circulation by antagonizing the biological function of VEGF.

Clinical significance

1. Predict the risk of preeclampsia;

2. Clinical diagnosis and prognosis of preeclampsia;

3. Reflect the growth of placental blood vessels and fetal growth restriction (FGR).

Profile of sFlt